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HIV
Infection Raises Lung Cancer Risk |
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Persons with
HIV infection
are at higher risk for developing lung cancer, independent of cigarette
smoking, a new study found.
Dr. Gregory D. Kirk of the Bloomberg School of Public Health at Johns
Hopkins University in Baltimore and colleagues examined lung cancer deaths
in a cohort of injection drug users followed since 1998 as part of an AIDS
study. Among the 2,086 participants, 27 lung cancer deaths were identified;
14 of the deaths occurred in subjects with HIV.
After adjusting for potentially confounding factors such as age, sex, and
smoking status, the researchers found HIV infection was associated with a
3.6-fold increased risk for lung cancer compared to HIV-negative status.
"As HIV-infected persons survive longer, we are continuing to see that
non-AIDS outcomes are becoming the primary causes of morbidity and
mortality. Our study suggests that the risks for these non-AIDS outcomes may
be modulated by HIV infection," said Kirk.
Kirk said his team plans to combine its data with other HIV and at-risk
cohort studies to confirm the association between HIV and lung cancer.
"Also, we are evaluating a series of smoking/tobacco related biomarkers in
HIV-infected and uninfected persons with similar smoking patterns to compare
if the biological effect of smoking differs by HIV status, and if so, is
this related to degree of immune suppression or to antiretroviral
treatment," he noted.
The study, "HIV Infection Is Associated with an Increased Risk for Lung
Cancer, Independent of Smoking," was published in Clinical Infectious
Diseases (2007;45(1):103-110).
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Reuters (07.06.07) |
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